Intranasal administration of polysulfide prevents neurodegeneration in spinal cord and rescues mice from delayed paraplegia after spinal cord ischemia
Background: Delayed paraplegia is a devastating complication of thoracoabdominal aortic surgery.Hydrogen sulfide (H2S) was reported to be protective in a mouse model of spinal cord ischemia and the beneficial effect of H2S has been attributed to polysulfides.The objective of this study was to investigate the effects of polysulfides on delayed parap